As the cannabis revolution continues to evolve, the science behind the plant has grown exponentially.  Due to the fact that there is little real federal interest in understanding the versatility of cannabis, private companies (that’s us!) are more than willing to pick up the torch, pun intended, to research and understand cannabis and how it interacts with our bodies.  One of the fundamental building blocks to comprehending cannabis is understanding the relationship between cannabinoids, heat, and human beings natural receptors of the molecules. Cannabinoids extend far beyond the basics of THC and CBD, and science is only beginning to uncover the possibilities these amazing and diverse chemicals hold.


To put it plainly, cannabinoids are a diverse group of chemical compounds that pair with cannabinoid receptors in the brain.  The most well-known and understood cannabinoids are tetrahydrocannabinol (THC) and cannabidiol (CBD).  While only THC produces psychoactive results, the extensive list of cannabinoids and their benefits grows continuously.  Both THC and CBD occur in plants as the acidified versions THCA and CBDA. Through the application of heat, the “A” is removed from the compound and resulting cannabinoids THC and CBD are achieved.  By understanding the variations of these two main cannabinoids, and revealing the intricacies of the cannabis plant, Evolve Formulas creates higher quality and more efficient products that target the specific needs a consumer may have.  The most notable example would be Evolve Formulas’ patented NanoSphere Delivery System™ that delivers cannabinoids directly into the bloodstream for immediate symptom relief. This is achieved by encapsulating cannabinoids in a lipid-protective layer for increased bioavailability, bioactivity and therapeutic potential.


Little do most people know, but the body has an entire system devoted to cannabinoids called the endocannabinoid system, or ECS.  The nature of the system is to provide and maintain balance of all systems that need to be regulated such as the immune, nervous, and gastrointestinal.  This could be part of the reason that cannabis treatments are so impactful when it comes to nervous and gastrointestinal issues. The ECS is a complex system of checks and balances that uses an array of naturally produced endocannabinoids that are sent out throughout the body to essentially receive status reports.  Only discovered in the 1980’s, the ECS is still in the infancy of understanding but each day new clues are being uncovered that help scientists understand how THC, CBD, and other cannabinoids would interact within the human body. The most prevalent naturally produced endocannabinoid is called anandamide.

Anandamide is produced in the parts of the brain that are integral for basic movement, pain tolerance, memory, and motivation.  There is speculation that the more anandamide naturally produced, the lesser need that person would have for cannabis. However, if someone were to be drastically lacking anandamide cannabis would be a natural remedy to help supplement.


Currently, there are only two main receptors of cannabinoids in the human brain.  These were not intended for receiving THC and CBD cannabinoids, but will accept them in place of naturally produced cannabinoids.  The CB1 and CB2 receptors operate like a lock and key mechanism in tandem with the cannabinoids. For instance, when THC is consumed, the chemical floods the body in search of a receptor (lock), and when found, unlocks a response that is then transmitted to the rest of the body.  When THC opens the “lock,” the body experiences the variety of “high” responses dependent on the more intricate details of the strain consumed. CBD works a bit differently in the human body, by increasing the amount of natural endocannabinoids through a process of altering enzymes. Science is just beginning to understand the many ways cannabinoids interact within the body and use the framework inherit to each human being.

Cannabinoid Receptor #1: These receptors are found most prevalently in the brain and nervous system.  Natural endocannabinoids and THC are the most common “keys” that bind to CB1.

Cannabinoid Receptor #2: CB2 receptors are more likely found in the immune system, specifically the spleen and gastrointestinal system. CB2 receptors are more likely to bind with CBD and helps to regulate appetite, pain management, and inflammation.


Understanding cannabinoids is at the heart of what Evolve Formulas is doing to push the industry standards of CBD and THC transdermal application.  With an innovative approach and patented technology, transdermal application of Evolve Formulas products is the result of a higher knowledge of cannabinoids and their interaction within our bodies.

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