The Importance of Consistent Delivery and CBD Bioavailability

Bioavailability is when a consumed substance is stored within the body for a slower release. It is then used in an efficient manner. This is important because it then provides greater health benefits to the individual.  

In the instance of orally consuming CBD, the excess will be stored within fat cells to allow for a release over the next several days if the individual consumes an adequate amount. However, it is important to note that taking CBD orally will not provide a person with the highest bioavailability. It is processed by digestive organs, such as the liver, and then enters the bloodstream. If this occurs too quickly, the CBD will not offer the same type of benefits as it would otherwise.  

It is said that consuming CBD orally over an extended period of time can help treat many different chronic conditions. Of course, you should seek the advice of a medical professional before making the decision to treat your condition using CBD. Also, you should know that not all of the CBD you ingest will make it to your endocannabinoid system, so the results can vary greatly depending on the delivery method of how you consume it and how it is processed by your body.  


Some Science Behind Bioavailability  

There is an issue with consuming medicine that is known as the first-pass effect. This has to do with how the liver metabolizes chemical compounds, as well as other digestive processes that occur. When something like CBD is taken orally, a large portion of it will never make it to the rest of the body. It will be broken down to components that cannot be used by the body. This seriously limits the bioavailability to the body's cells.  

A study was conducted by Zhornitsky and Potvin, which led to the definition of high-dose in terms of oral CBD as between 150 and 600 mg per day. Numerous individuals have claimed benefits from consuming amounts as small as a 15 mg capsule twice a day, taking it in the morning and at night.  

Delivery Methods of CBD  

The various means of consuming CBD each offer different benefits due to their bioavailability levels. For instance, oral consumption provides 6 to 15 percent bioavailability. When the individual takes CBD through vaping, bioavailability is at 40 percent since it is absorbed through the lungs.  

The use of certain products, such as tinctures and sprays, can improve bioavailability. Something that is absorbed directly by mouth is known as oromucosal. One particular spray that contains a 1:1 ratio of CBD and THC has a rate of up to 90 percent absorption, according to several studies. When the individual holds the spray or tincture in his or her mouth for a longer amount of time, the absorption is increased. It is recommended to hold CBD liquid under your tongue for 30 to 60 seconds to have optimal absorption.  


Vaping with an oil that has been infused with CBD means that it will enter your lungs and get diffused into your bloodstream at a relatively fast rate (within a few minutes, with the effects wearing off within 2 to 3 hours). Since it gets through the blood and blood-brain barrier at such a fast rate, the first-pass effect is bypassed and up to three times the amount of CBD is able to circulate your body for between 40 to 60 percent bioavailability. It is a method that is ideal for treating acute symptoms quickly. Using a high-CBD concentrate or an e-liquid containing CBD is your best bet in terms of feeling the effects more quickly.   

As with any form of medication, it is important to start off at a low dosage and then increase the amount and variety of CBD delivery methods. A safe bet is to start with about 15 mg a day. You can figure out the best dosage for your needs within a short period of time.  

Evolve's NanoSerum™

Clinical testing has shown that Evolve's NanoSphere Delivery System™ technology make it a more effective product.Using advanced nanobiotechnology, Evolve encapsulates, protects and transports cannabinoids in a protective lipid membrane called NanoSpheres. When cannabis is delivered to cells and tissues in nano-sized bites, they can be absorbed and used immediately, bypassing destruction the liver and much of the GI tract. The high quality, purity and fast-acting results of Evolve’s NanoSerum™ makes this a product that you truly can trust.

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