What is Evolve NanoSerum™?

Evolve’s NanoSerum™ is a fast-acting, ultra-strength transdermal formula infused with nano-encapsulated cannabis and cannabis extracts. NanoSerum™ immediately penetrates the skin to deliver direct-focused relief and intelligently carries a full spectrum of cannabinoids and phytochemicals to receptors throughout the body for systemic response.

Why should I buy NanoSerum™ over the competition?

Straight up, because it will work better for you and you will know it within a couple minutes of applying it. It works better because there is better research behind it. Research that our patents protect and that keeps us on the leading edge of product innovation and effectiveness. In short, we deliver the results you need faster, longer, and more conveniently.

How does nano-sizing improve bioavailability?

Patented NanoSphere Delivery System™ nano-encapsulates cannabis molecules in a protective lipid matrix, enabling them to quickly and effectively cross the skin barrier into body tissues and cells, for faster, longer-lasting action.

Is it a patch?

No, our product is a one-of-a-kind NanoGel™ that is applied directly to the skin and is absorbed almost immediately and begins to act within minutes of applying it. While most patches are sold on the promise of delivering sustained benefits over longer periods of time, NanoSerum™ not only acts much faster, it also has longer, more pronounced benefits. Results are both faster and longer-lasting.

What evidence do you have to support your claims?

The core nanotechnology that underpins our patented NanoSphere Delivery System™ is utilized by the pharmaceutical industry and has taken the lead over other delivery technologies because it enhances biocompatibility, safety and versatility. NanoSphere Health also conducts our own clinical studies on pharmacokinetics and pharmacodynamics. Please see our Clinical Study Summary for complete results, click here.

How does it smell and is it oily or greasy?

NanoSerum™ is a soothing fluid gel with a natural aromatic scent of spearmint and rosemary that is absorbed immediately, leaving no oily or greasy residue.

Only the finest pharmaceutical-grade isolated cannabinoids, terpenes, cannabis extracts and GRAS ingredients are used in making Evolve’s products. All ingredients are 100% pure, biodegradable and biocompatible. Evolve products contain NO: artificial colors or fragrance. NO animals were tested in the making of our products.

What ingredients are in NanoSerum™?

  • Faster onset of action, within minutes, compared to an hour or more with standard ingested cannabis extracts and even longer with patches and most topicals

  • Smart nanoparticle biotechnology improves cannabinoid-to-receptor binding and amplifies signal transduction

  • Delivers higher concentration of bioactive cannabinoids and terpenes to target tissues

  • Increases bioavailability of cannabinoids

  • Consistent, precision-metered microliter dose at every use

  • Decreased dosages required for same effect

  • Enhances stability of active ingredients and decreased adverse effects

  • More efficacious cannabinoid therapy

  • Extended circulating half-life

  • Fast-acting, convenient and easy-to-use anywhere

What are some of the benefits of Evolve and its NanoSphere Delivery System™? 

Evolve cannabis products are soon to be available in licensed dispensaries in California and Canada. See our store locator for a current list of all locations.

Where can I buy Evolve cannabis products?

Since we use whole cannabis oil, our products are not shippable in the U.S. at this time under Federal Law. Products will be available for shipping within Canada very soon.

Can you ship products to me?


NanoSerum Ingredients and Benefits:

△9 -Tetrahydrocannabinol (THC)

THC is the strongest pain relieving cannabinoid in NanoSerum™ and the cannabis plant. THC’s powerful pain relieving actions result primarily from stimulating the CB1 receptors of the endocannabinoid system that reduce pain, inflammation and abnormally heightened sensitivity to pain.

Cannabidiol (CBD)

CBD is a non-euphoriant cannabinoid that acts as an endocannabinoid modulator. CBD alters THC function by inhibiting its 1st pass liver formation into the more psychoactive 11-hydroxy-THC, which prevents feeling THC’s psychotropic effect of being high.

Cannabigerol (CBG)

CBG is a cannabinoid that provides more potent pain-reducing, anti-erythema (skin redness) and anti-inflammatory pain blocking activity than THC.

△9- Tetrahydrocannabinlic acid (THCA)

THCA is the non-euphoriant cannabinoid precursor of THC in cannabis plant. THCA works synergistically with THC in activating CB1 receptors for pain relief and relieving inflammation.


Myrcene produces peripheral pain relief from its opioid-like activity. Myrcene blocks inflammation by inhibiting inflammatory and neuropathic pain.


𝛽-caryophyllene is a CB2 receptor stimulant with anti-inflammatory effects comparable to phenylbutazone.


𝛽-sitosterol is a phytosterol found in cannabis that reduces topical inflammation.


Menthol, a natural terpene in peppermint, provides topical pain relief by activating and desensitizing epidermal pain receptors.


Resveratrol Also known as the “longevity molecule,” his potent antioxidant helps to neutralize free radicals and studies have shown its potential benefits in anti-aging and antioxidant effects.