What is Evolve NanoSerum™?

Evolve’s NanoSerum™ is a fast-acting, ultra-strength transdermal formula infused with nano-encapsulated cannabis and cannabis extracts. NanoSerum™ immediately penetrates the skin to deliver direct-focused relief from pain, inflammation and anxiety and intelligently carries a full spectrum of cannabinoids and phytochemicals to receptors throughout the body for systemic healing.

Why should I buy NanoSerum™ over the competition?

NanoSerum™ is the first and ONLY transdermal delivered cannabinoid formulation with a clinically-proven and patented NanoSphere Delivery System™ to rapidly transport THC and other cannabinoids across the dermis into systemic circulation. This is the only product in the market that has been tested in human pharmacokinetic blood studies.

How does our delivery system work?

Utilizing the world’s first and only scientifically supported nanoparticle delivery system for cannabis, Evolve’s NanoSerum™ is the sole cannabis transdermal on the market that can penetrate the five layers of skin to deliver beneficial cannabinoids into the bloodstream and systemic circulation within minutes. Evolve nano-encapsulates active ingredients in natural, lipid membranes for rapid transportation and unparalleled absorption and bioavailability.

How does nano-sizing improve bioavailability?

Nano-sizing maximizes the surface area of the cannabinoid molecule. As dimensions decrease from nano-sizing the surface increases exponentially. This can dramatically improves absorption, distribution and bioavailability

Is nano-sizing safe?

Evolve is committed to ensuring that its products are consistently pure and safe. Our formulas are formed exclusively from pharmaceutical grade, biocompatible, non-toxic and GRAS (Generally Recognized as Safe) ingredients. Each ingredient is recognized as being safe when administered to the human body in our product’s dosage forms in nano- scale dimensions. Because our formulas contain no fillers, binders or additives, you get only pure ingredients.

Is it a patch?

No, our product is a viscoelastic NanoGel™ that is absorbed within seconds of applying! There is no need for an inconvenient patch or the mess of applying other salves, lotions or creams. Patches and other topical pain relief products are slow acting and ineffective – typically taking 5-24 hours to reach appreciable levels in the blood.

What evidence do you have to support your claims?

The science behind our patented NanoSphere Delivery System has been verified by various independent pharmacological and scientific journals, peer-reviewed articles and clinical trials. The underlying form of our patented NanoSphere Delivery System™ is utilized by the pharmaceutical industry and has taken the lead over other delivery technologies because of advantages of higher degree of biocompatibility, safety and versatility. NanoSphere Health also conducts our own clinical studies on pharmacokinetics and pharmacodynamics. Please see our Clinical Study Summary for complete results, click here.

Does it leave a smell?

NanoSerum™ is a soothing fluid gel with a natural aromatic scent of spearmint and rosemary. Our serum is absorbed immediately.

What kind of problems can NanoSerum™ treat?

  • For pain, muscle aches, tension and soreness, apply to the affected area of the body.

  • For quick relief headaches, apply to the temples and forehead.

  • To comfort menstrual cramps and abdominal pain, apply to the abdominal area of discomfort.

  • To ease joint pain or stiffness, apply to skin around painful joints and vertebrae.

  • To relieve anxiety, apply to pulse points such as the inner wrists.

Only the finest pharmaceutical-grade isolated cannabinoids, terpenes, cannabis extracts and ingredients are used in making Evolve’s products. All ingredients are 100% pure, biodegradable, biocompatible and non-toxic. Only organic pesticides, fungicides or herbicides during the cultivation of the cannabis are used in our products. Evolve contains NO: synthetic ingredients, chemicals, mineral oils, petroleum, artificial colors or fragrance. NO animals were tested in the making of our products.

What ingredients are in NanoSerum™?

  • Faster onset of actions, within minutes, compared to an hour or more with standard ingested cannabis extracts

  • Smart nanoparticle biotechnology improves cannabinoid-to-receptor binding and amplifies signal transduction

  • Delivers higher concentration of bioactive cannabinoids and terpenes

  • Increases bioavailability of cannabinoids (2-fold to 8-fold)

  • Consistent, precision-metered microliter dose at every use

  • Decreased dosages (2-fold to 8-fold)

  • Decreased adverse effects

  • Decreases development of tolerance to cannabis from prolonged use

  • More efficacious cannabinoid therapy

  • Extended circulating half-life

  • Fast-acting, convenient and easy-to-use anywhere

  • Safer, long-term use.

What are some of the benefits of Evolve and its NanoSphere Delivery System™? 

Evolve cannabis products are available in licensed dispensaries in Colorado. See our store locator for a current list of all locations.

Where can I buy Evolve cannabis products?

Since we use whole cannabis oil, our products are not shippable at this time under Federal Law. 

Can you ship products to me?


About Our Serum

What is it?

A serum is a product characterized by its rapid absorption and ability to penetrate into the deeper layers of the skin. Advanced NanoSerum™ goes beyond skin deep, precisely delivering healing cannabinoids and terpenes locally and systemically for immediate relief.

What is the difference between a serum, lotion, cream or salve?

The biggest difference between a serum and a cream or lotion is what the formulation doesn’t include. Our serum is free of unnatural fats, lubricants, thickeners, chemicals and harmful excipients that form the other creams, lotions and salves. Only natural, pure ingredients and nano-sized cannabis make up our patented formulation.

Active Ingredients:

NanoSerum™ delivers a full spectrum of cannabis extracts, terpenes and phytonutrients to provide intensive, immediate relief deep into the layers of you skin, bloodstream and cells.

Texture and Scent

NanoSerum™ is soothing fluid gel with natural aromatic scent of spearmint and rosemary verbenone. It nourishes, protects and heals the skin and the ingredients are nano-sized so the serum can be absorbed immediately!


Since the active ingredients in NanoSerum™ are nano-sized, making them highly potent and able to penetrate deeply into the skin, our NanoSerum™ is able to produce more results you can feel in less time than a simple lotion or cream. This makes NanoSerum™ a great tool for targeting specific concerns, like muscle soreness, inflammation, tension, insomnia or anxiety. Say goodbye to waiting for relief!

NanoSerum™ Ingredient Summary

NanoSerum™ contains a research-proven profile of nano-sized cannabinoids and cannabis terpenes. Nano-encapsulated cannabis and cannabis extracts have been scientifically-proven to be absorbed directly into the bloodstream to bind to the CB1 and CB2 receptors to maximum pain reduction and therapeutic benefits with synergistic entourage effects.


The phytocannbinoids derived from cannabis alleviate pain through the CB1 and CB2 endocannabinoid system receptor mechanisms and non-receptor mechanisms, which include direct pain relief, anti-inflammatory actions, cramping, headache relief and anti-anxiety properties.

Terpenes and Favones

Cannabis terpenes and flavones in NanoSerum™ produce many complementary pain relieving and therapeutic effects.

Ingredients and benefits:

△9 -Tetrahydrocannabinol (THC)

THC is the strongest pain relieving cannabinoid in NanoSerum™ and the cannabis plant. THC’s powerful pain relieving actions result primarily from stimulating the CB1 receptors of the endocannabinoid system that reduce pain, inflammation and abnormally heightened sensitivity to pain.

Cannabidiol (CBD)

CBD is a non-euphoriant cannabinoid that acts as an endocannabinoid modulator. CBD alters THC function by inhibiting its 1st pass liver formation into the more psychoactive 11-hydroxy-THC, which prevents feeling THC’s psychotropic effect of being high.

Cannabigerol (CBG)

CBG is a cannabinoid that provides more potent pain-reducing, anti-erythema (skin redness) and anti-inflammatory pain blocking activity than THC.

△9- Tetrahydrocannabinlic acid (THCA)

THCA is the non-euphoriant cannabinoid precursor of THC in cannabis plant. THCA works synergistically with THC in activating CB1 receptors for pain relief and relieving inflammation.


Myrcene produces peripheral pain relief from its opioid-like activity. Myrcene blocks inflammation by inhibiting inflammatory and neuropathic pain.


𝛽-caryophyllene is a CB2 receptor stimulant with anti-inflammatory effects comparable to phenylbutazone.


𝛽-sitosterol is a phytosterol found in cannabis that reduces topical inflammation.


Menthol, a natural terpene in peppermint, provides topical pain relief by activating and desensitizing epidermal pain receptors.


Resveratrol Also known as the “longevity molecule,” his potent antioxidant helps to neutralize free radicals and studies have shown its potential benefits in anti-aging and antioxidant effects.